Pantothenamides are secondary or tertiary amides of pantothenic acid, Axitinib the vitamin precursor from the critical cofactor and universal acyl carrier coenzyme A. A recent research has demonstrated that pantothenamides inhibit the growth of blood-stage Plasmodium falciparum with submicromolar potency by exerting an effect on pantothenic acid utilization, but only once the pantetheinase present from the growth medium continues to be inactivated. Here, we show that tiny modifications from the pantothenamide core construction are enough to counteract pantetheinase-mediated degradation and that the resultingselleck chemicals llc pantothenamide analogues nonetheless inhibit the in vitro proliferation of P. falciparum by targeting a pantothenic acid-dependent system (or processes). Lastly, we investigated the toxicity with the most potent analogues to human cells and show that the selectivity ratio exceeds a hundred in 1 case. Taken together, these benefits supply additional support for selleck chemical pantothenic acid utilization currently being a viable target for antimalarial drug discovery.